To get the best performance out of VMware’s iSCSI initiator it’s a good idea to enable jumbo frames on the ESX hosts.  First configure a new vSwitch dedicated to the iSCSI network and if you’re doing this in the GUI delete the default port group that is created.

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Here’s a tip if your ESX host freaks out and you happen to be storing a VMFS partition on the same volume as ESX: 

If an “upgrade” install doesn’t fix the problem then do a clean install and on the page that shows how it will cut up the partitions there is a checkbox that says not to touch the existing VMFS partitions on the volume.  Leave that checked and then proceed with the install. 

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